Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination
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چکیده
منابع مشابه
Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy By
Objective: Diabetes is heterogeneous group of disorders characterized by aberrant insulin signaling and hyperglycmia. Chronic hypergylcemia leads to the development of complications including diabetic peripheral neuropathy (DPN). DPN is a pervasive complication associated with diabetes and its development is not completely understood. Research Design and Methods: We aimed to determine if ErbB2 ...
متن کاملNeuregulin-1 Enhances Depolarization-Induced GABA Release
Neuregulin-1 (NRG1), a regulator of neural development, has been shown to regulate neurotransmission at excitatory synapses. Although ErbB4, a key NRG1 receptor, is expressed in glutamic acid decarboxylase (GAD)-positive neurons, little is known about its role in GABAergic transmission. We show that ErbB4 is localized at GABAergic terminals of the prefrontal cortex. Our data indicate a role of ...
متن کاملCaveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy
OBJECTIVE Evaluate if Erb B2 activation and the loss of caveolin-1 (Cav1) contribute to the pathophysiological progression of diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS Cav1 knockout and wild-type C57BL/6 mice were rendered diabetic with streptozotocin, and changes in motor nerve conduction velocity (MNCV), mechanical and thermal hypoalgesia, Erb B2 phosphorylation (pEr...
متن کاملCaveolin-1 scaffolding domain peptides enhance anti-inflammatory effect of heme oxygenase-1 through interrupting its interact with caveolin-1
Caveolin-1(Cav-1) scaffolding domain (CSD) peptides compete with the plasma membrane Cav-1, inhibit the interaction of the proteins and Cav-1, and re-store the functions of Cav-1 binding proteins. Heme oxygenase-1 (HO-1) binds to Cav-1 and its enzymatic activity was inhibited. In this study, we investigated the effect of CSD peptides on interaction between HO-1 and Cav-1, and on the HO-1 activi...
متن کاملDissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice.
Hyperglycemia and endothelial dysfunction are associated with hypertension, but the specific causality and genetic underpinning are unclear. Caveolin-1 (cav-1) is a plasmalemmal anchoring protein and modulator of vascular function and glucose homeostasis. Cav-1 gene variants are associated with reduced insulin sensitivity in hypertensive individuals, and cav-1(-/-) mice show endothelial dysfunc...
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ژورنال
عنوان ژورنال: Glia
سال: 2008
ISSN: 0894-1491,1098-1136
DOI: 10.1002/glia.20662